MC31504 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 [23007-85-4]
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详情
| 英文名称 | 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Hydrochloride |
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| 别名 | MPTP, 1-甲基-4-苯基-1,2,3,6-四氢嘧啶;1-甲基-4-苯基-1,2,3,6-四氢嘧啶盐酸盐;1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Hydrochloride;Mptp Hydrochloride;Mptp;N-Methyl-4-Phenyl-1,2,3,6-Tetrahydro |
| 分子式 | C12H16ClN |
| CAS号 | 23007-85-4 |
| 分子量 | 209.72 |
| MDL | MFCD00012790 |
| 名称 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 |
| 介绍 | ≥98%（HPLC） |
文档信息
| 文档 | COA NMR HPLC MSDS Datasheet |
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生物活性
| 描述 | MPTP hydrochloride是可渗透血脑屏障的 多巴胺 神经毒素，能诱导帕金森综合症。 |
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| 相关类别 |
研究领域 >>神经疾病 信号通路 >> 其他>> 其他 |
| 体外研究 | 用50mM 4-苯基吡啶预处理，使小鼠膈神经 - 膈肌中MPTP（50％抑制抽搐振幅的浓度）值从53降至18mM，d-筒箭毒素分别降至0.7至0.3mM [3]。 |
| 动物实验 | 为了制备LPS大鼠模型和MPTP小鼠模型，进行动物的处理。简而言之，成年大鼠在以下坐标（AP-4.2 mm，L 1.5 mm和V 7.8 mm）处单侧注射LPS（0.5μL10μg/μL稀释于0.9％盐水中）至内侧前脑束（MFB），并用相同体积的0.9％生理盐水进入对侧。给成年小鼠腹膜内注射25mg / kg的MPTP连续5天，并注射相同体积的盐水作为对照。在LPS或MPTP注射后第1,2,3或4周处死所有动物。收集脑样品用于随后的免疫组织化学和蛋白质印迹实验。 |
| 参考文献 |
[1]. Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12. [2]. Desole M S, et al. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat. Source:Pharmacol.Biochem.Behav., 1996, 54, No. 2, 377-83. [3]. Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83. [4]. Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180. |
物理化学性质
| 沸点 | 258.6ºC at 760mmHg |
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| 分子式 | C12H16ClN |
| 分子量 | 209.715 |
| 闪点 | 105.8ºC |
| 精确质量 | 209.097122 |
| PSA | 3.24000 |
| LogP | 3.14540 |
| 蒸汽压 | 0.0136mmHg at 25°C |
英文别名
| 别名 |
MPTP Hydrochloride 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Pyridine, 1,2,3,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride (1:1) Pyridine, 1,2,5,6-tetrahydro-1-methyl-4-phenyl-, hydrochloride 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineHydrochloride 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (1:1) 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine hydrochloride 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine,hydrochloride 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium chloride MPTP (hydrochloride) |
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