MC80757 Oxytocin 50-56-6 缩宫素

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 催产素受体

1: Carter CS, Kenkel WM, MacLean EL, Wilson SR, Perkeybile AM, Yee JR, Ferris CF, Nazarloo HP, Porges SW, Davis JM, Connelly JJ, Kingsbury MA. Is Oxytocin"Nature's Medicine"? Pharmacol Rev. 2020 Oct;72(4):829-861. doi:10.1124/pr.120.019398. PMID: 32912963; PMCID: PMC7495339.

2: Love TM. Oxytocin, motivation and the role of dopamine. Pharmacol Biochem Behav. 2014 Apr;119:49-60. doi: 10.1016/j.pbb.2013.06.011. Epub 2013 Jul 9.PMID: 23850525; PMCID: PMC3877159.

3: Jones C, Barrera I, Brothers S, Ring R, Wahlestedt C. Oxytocin and social functioning. Dialogues Clin Neurosci. 2017 Jun;19(2):193-201. doi:
10.31887/DCNS.2017.19.2/cjones. PMID: 28867943; PMCID: PMC5573563.

4: Leong KC, Cox S, King C, Becker H, Reichel CM. Oxytocin and Rodent Models of Addiction. Int Rev Neurobiol. 2018;140:201-247. doi: 10.1016/bs.irn.2018.07.007. Epub 2018 Aug 14. PMID: 30193705; PMCID: PMC6530803.

5: Cardaillac C, Rua C, Simon EG, El-Hage W. L’ocytocine et la dépression du post-partum [Oxytocin and postpartum depression]. J Gynecol Obstet Biol Reprod (Paris). 2016 Oct;45(8):786-795. French. doi: 10.1016/j.jgyn.2016.05.002. Epub
2016 Jun 14. PMID: 27312097.

6: Kendrick KM, Guastella AJ, Becker B. Overview of Human Oxytocin Research. Curr Top Behav Neurosci. 2018;35:321-348. doi: 10.1007/7854_2017_19. PMID: 28864976.

7: Marsh N, Marsh AA, Lee MR, Hurlemann R. Oxytocin and the Neurobiology of Prosocial Behavior. Neuroscientist. 2021 Dec;27(6):604-619. doi:
10.1177/1073858420960111. Epub 2020 Sep 26. PMID: 32981445; PMCID: PMC8640275.

8: Giel K, Zipfel S, Hallschmid M. Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives. Curr Neuropharmacol.
2018;16(8):1111-1121. doi: 10.2174/1570159X15666171128143158. PMID: 29189166;
PMCID: PMC6187754.

9: Bhargava R, Daughters KL, Rees A. Oxytocin therapy in hypopituitarism: Challenges and opportunities. Clin Endocrinol (Oxf). 2019 Feb;90(2):257-264. doi: 10.1111/cen.13909. Epub 2018 Dec 17. PMID: 30506703.

10: Oettl LL, Kelsch W. Oxytocin and Olfaction. Curr Top Behav Neurosci. 2018;35:55-75. doi: 10.1007/7854_2017_8. PMID: 28812265.

1.疏水参数计算参考值（XlogP）:-2.6

2.氢键供体数量:12

3.氢键受体数量:13

4.可旋转化学键数量:17

5.互变异构体数量:1001

6.拓扑分子极性表面积400

7.重原子数量:69

8.表面电荷:0

9.复杂度:1870

10.同位素原子数量:0

11.确定原子立构中心数量:9

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

1. 性状：为白色无定形粉末，微有异臭

2. 密度（g/mL,25/4℃）：未确定

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：192-194°C

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,5.2kPa）：未确定

7. 折射率：未确定

8. 闪点（ºC）：未确定

9. 比旋光度（º）：-26.2°, C=0.53, DIOXANE

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（kPa,25 ºC）：未确定

12. 饱和蒸气压（kPa,60ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19. 溶解性：易溶于水，溶于丙酮、丁醇和稀醋酸，不溶于乙醚和石油醚

Pitocin

Synpitan

α-Hypophamine Oxytocic hormone

Oxystin

L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic (1®6)-disulfide

Uteracon

Syntocinone

MFCD00076731

EINECS 200-048-4

(2S)-1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-N-{(1S)-1-[(2-amino-2-oxoethyl)carbamoyl]-3-methylbutyl}pyrrolidine-2-carboxamide

1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-2-butanyl]-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-leucylglycinamide

α-Hypophamine

Oxtocin

Nobitocin S

1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-leucylglycinamide

Atonin O