MCS134380 SEW2871 [256414-75-2]
![MCS134380 SEW2871 [256414-75-2]](https://mxbioscience.com/media/catalog/product/cache/2/image/9df78eab33525d08d6e5fb8d27136e95/m/c/mcs134380.gif)
详情
| 英文名称 | SEW2871 |
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| 别名 | ;5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole |
| 分子式 | C20H10F6N2OS |
| CAS号 | 256414-75-2 |
| 分子量 | 440.36 |
| MDL | MFCD00096600 |
| 名称 | SEW2871 |
| 介绍 | >98%评论 |
| 属性 | 存贮条件 储存温度2-8°C |
文档信息
| 文档 | COA NMR HPLC MSDS Datasheet |
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生物活性
| 描述 | SEW2871 是高度选择性的，具有口服活性的 S1P1 激动剂，EC50 为 13.8 nM。SEW2871 激活 ERK，Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。SEW2871 减少血液中的淋巴细胞数量，并在糖尿病，阿尔茨海默氏病，肝纤维化和炎症反应方面具有治疗意义。 |
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| 靶点 | EC50: 13.8 nM (S1P1)[2] |
| 参考文献 | [1]. Park SJ, et al. Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery. Biomol Ther (Seoul). 2017 Jan 1;25(1):80-90. [2]. Jo E, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. 2005 Jun;12(6):703-15. [3]. Dong J, et al. Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol. 2014 Jul;177(1):94-101. |
物理化学性质
| 密度 | 1.4±0.1 g/cm3 |
|---|---|
| 沸点 | 490.3±55.0 °C at 760 mmHg |
| 熔点 | 94.5-95.3ºC |
| 分子式 | C20H10F6N2OS |
| 分子量 | 440.362 |
| 闪点 | 250.3±31.5 °C |
| 精确质量 | 440.041809 |
| PSA | 67.16000 |
| LogP | 8.42 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 0.0±1.2 mmHg at 25°C |
| 折射率 | 1.535 |
文献
| [1] | Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells. |
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| [2] | Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. |
| [3] | Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. |
英文别名
| 别名 | 1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole 5-[4-phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole |
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