MCS8874 PLX5622 [1303420-67-8]

信号通路 >> 蛋白酪氨酸激酶 >> c-FMS
研究领域 >> 神经疾病

2-month-old wild-type mice were treated with vehicle or PLX5622 at 300- or 1200 mg/kg in chow for 7 or 21 days.2 month-old wild-type mice were treated with 300 or 1200 mg/kg PLX5622 or vehicle for 14 days, and LPS or PBS was then administered via IP (0.5 mg/kg).^[1]

[1] Microglial depletion does not affect behavior or learning and memory

[2]Microglial elimination with PLX5622 followed by drug removal results in rapid repopulation of the CNS

[3]PLX5622 improves cognition in aged 3xTg-AD mice Lower-dose

[4]PLX5622 treatment partially reduces microglial numbers

[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.
[2]Rosin JM, Vora SR, Kurrasch DM. Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour. Brain Behav Immun. 2018 Oct;73:682-697. doi: 10.1016/j.bbi.2018.07.023. Epub 2018 Jul 27. PMID: 30056204.
[3]Huang Y, Xu Z, Xiong S, Sun F, Qin G, Hu G, Wang J, Zhao L, Liang YX, Wu T, Lu Z, Humayun MS, So KF, Pan Y, Li N, Yuan TF, Rao Y, Peng B. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nat Neurosci. 2018 Apr;21(4):530-540. doi: 10.1038/s41593-018-0090-8. Epub 2018 Feb 22. PMID: 29472620.
[4]Takeda A, Shinozaki Y, Kashiwagi K, Ohno N, Eto K, Wake H, Nabekura J, Koizumi S. Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. Glia. 2018 Nov;66(11):2366-2384. doi: 10.1002/glia.23475. Epub 2018 Oct 29. PMID: 30375063.
[5]Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. doi: 10.1016/j.expneurol.2019.04.011. Epub 2019 Apr 25. PMID: 31029597; PMCID: PMC6615458.