MC27361 依普利酮 [107724-20-9]
![MC27361 依普利酮 [107724-20-9]](https://mxbioscience.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/1/0/107724-20-9.gif)
Details
| 英文名称 | Eplerenone |
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| 别名 | Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester |
| 分子式 | C24H30O6 |
| CAS号 | 107724-20-9 |
| 分子量 | 414.49 |
| MDL | NA |
| 名称 | 依普利酮 |
| 介绍 | 98% |
文档信息
| 文档 | COA NMR HPLC MSDS Datasheet |
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生物活性
| 描述 | Eplerenone是醛固酮拮抗剂，IC50为360nM。 |
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| 相关类别 |
研究领域 >> 心血管疾病 信号通路 >> 代谢酶/蛋白酶 >>盐皮质激素受体 |
| 参考文献 |
[1]. Chatterjee, S., et al., Eplerenone is not superior to older and less expensive aldosterone antagonists. Am J Med, 2012. 125(8): p. 817-25. [2]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62. |
物理化学性质
| 密度 | 1.3±0.1 g/cm3 |
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| 沸点 | 597.9±50.0 °C at 760 mmHg |
| 熔点 | 241-243ºC |
| 分子式 | C24H30O6 |
| 分子量 | 414.491 |
| 闪点 | 259.5±30.2 °C |
| 精确质量 | 414.204254 |
| PSA | 82.20000 |
| LogP | 1.05 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 0.0±1.7 mmHg at 25°C |
| 折射率 | 1.587 |
| 分子结构 |
1、 摩尔折射率：106.12 2、 摩尔体积（m3/mol）：315.6 3、 等张比容（90.2K）：851.9 4、 表面张力（dyne/cm）：53.0 5、 极化率（10 -24 cm 3）：42.07 |
| 更多 |
1.性状：白色或类白色结晶性粉末，无味 2.熔点（ºC）：241~243。 3.溶解性：极微溶于水。 |
英文别名
| 别名 |
Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-diméthyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tétradécahydro-3H,3'H-spiro[cyclopenta[7,8]phénanthro[4b,5-b]oxirène-7,2'-furane]-10-carboxylate de méthyle Methyl-(4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxiren-7,2'-furan]-10-carboxylat Inspra EplerenoneC24H3006 9,11a-Epoxy-17-hydroxy-3-oxo-17a-pregn-4-ene-7a,21-dicarboxylic Acid g-Lactone Methyl Ester Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate Elperenone Epleremone epoxymexrenone Eplerenone spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 Spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)- Methyl (4aS,4bR,5aR,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate Spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7(3H),2'(3'H)-furan]-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7R,9aS,9bR)- 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester EPLERINONE |
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