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MCH602009 猪神经调节肽U-8 [98395-75-6]

MCH602009 猪神经调节肽U-8 [98395-75-6] 结构图

Details

英文名称 Neuromedin (U8), porcine
别名 NA
分子式 C54H78N16O10
CAS号 98395-75-6
分子量 1111.3
MDL NA
名称 猪神经调节肽U-8
介绍

存储温度 2-8℃
纯度 ≥95% or 98%

参考文献

1: De Prins A, Allaoui W, Medrano M, Van Eeckhaut A, Ballet S, Smolders I, De
Bundel D. Effects of neuromedin U-8 on stress responsiveness and hypothalamus-
pituitary-adrenal axis activity in male C57BL/6J mice. Horm Behav. 2020
May;121:104666. doi: 10.1016/j.yhbeh.2019.104666. Epub 2020 Mar 2. PMID:
31899262.

2: Masuda Y, Kumano S, Noguchi J, Sakamoto K, Inooka H, Ohtaki T. PEGylated
neuromedin U-8 shows long-lasting anorectic activity and anti-obesity effect in
mice by peripheral administration. Peptides. 2017 Aug;94:99-105. doi:
10.1016/j.peptides.2017.04.001. Epub 2017 Apr 8. PMID: 28400225.

3: Minamino N, Kangawa K, Matsuo H. Neuromedin U-8 and U-25: novel uterus
stimulating and hypertensive peptides identified in porcine spinal cord. Biochem
Biophys Res Commun. 1985 Aug 15;130(3):1078-85. doi:
10.1016/0006-291x(85)91726-7. PMID: 3839674.

4: Sumi S, Inoue K, Kogire M, Doi R, Takaori K, Suzuki T, Yajima H, Tobe T.
Effect of synthetic neuromedin U-8 and U-25, novel peptides identified in
porcine spinal cord, on splanchnic circulation in dogs. Life Sci. 1987 Sep
28;41(13):1585-90. doi: 10.1016/0024-3205(87)90725-9. PMID: 3626773.

5: Honzawa M, Sudoh T, Minamino N, Kangawa K, Matsuo H. Neuromedin U-like
immunoreactivity in rat intestine: regional distribution and immunohistochemical
study. Neuropeptides. 1990 Jan;15(1):1-9. doi: 10.1016/0143-4179(90)90153-p.
PMID: 2325835.

6: Hashimoto T, Kurosawa K, Sakura N. Structure-activity relationships of
neuromedin U. II. Highly potent analogs substituted or modified at the
N-terminus of neuromedin U-8. Chem Pharm Bull (Tokyo). 1995 Jul;43(7):1154-7.
doi: 10.1248/cpb.43.1154. PMID: 7586059.

7: Malendowicz LK, Nussdorfer GG, Markowska A, Tortorella C, Nowak M, Warchol
JB. Effects of neuromedin U (NMU)-8 on the rat hypothalamo-pituitary-adrenal
axis. Evidence of a direct effect of NMU-8 on the adrenal gland. Neuropeptides.
1994 Jan;26(1):47-53. doi: 10.1016/0143-4179(94)90092-2. PMID: 8159286.

8: Domin J, Ghatei MA, Chohan P, Bloom SR. Neuromedin U--a study of its
distribution in the rat. Peptides. 1987 Sep-Oct;8(5):779-84. doi:
10.1016/0196-9781(87)90058-1. PMID: 3432125.

9: Kurosawa K, Sakura N, Hashimoto T. Structure-activity relationships of
neuromedin U. III. Contribution of two phenylalanine residues in dog neuromedin
U-8 to the contractile activity. Chem Pharm Bull (Tokyo). 1996
Oct;44(10):1880-4. doi: 10.1248/cpb.44.1880. PMID: 8904815.

10: De Prins A, Martin C, Van Wanseele Y, Skov LJ, Tömböly C, Tourwé D,
Caveliers V, Van Eeckhaut A, Holst B, Rosenkilde MM, Smolders I, Ballet S.
Development of potent and proteolytically stable human neuromedin U receptor
agonists. Eur J Med Chem. 2018 Jan 20;144:887-897. doi:
10.1016/j.ejmech.2017.12.035. Epub 2017 Dec 14. PMID: 29329072.

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