Anti-BACE1 / BACE Antibody (aa140-154) MX-C2952
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide from human BACE1. Percent identity by BLAST analysis: Human (100%). |
|---|---|
| conjugations | Unconjugated |
| epitope | aa140-154 |
| furification | Protein G purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (aa140-154) MX-C2952 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | KLH conjugated synthetic peptide comprising amino acids 140 - 154 [ELGTDLPDDSLEPFF] of the human beta-site APP-cleaving enzyme 1 isoform C (BACE) protein. |
| storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| target | BACE1 / BACE |
| predicted | aa140-154 |
| format | Unconjugated |
| clonality | Polyclonal |
| approved | ELISA (1:1000) |
| application | ELISA |