Anti-BACE1 / BACE Antibody (aa72-121, HRP) MX-C449355
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide located between aa72-121 of human BACE1 (P56817, NP_036236). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, |
|---|---|
| conjugations | Horseradish Peroxidase.Also available Unconjugated or conjugated with Biotin, FITC. |
| epitope | aa72-121 |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (aa72-121, HRP) MX-C449355 |
| modifications | Unmodified |
| reactivity | Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Hamster, Horse, Pig, Rabbit |
| ncbi | P56817 |
| reconstitution | Chicken, Zebrafish (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Human BACE1 |
| storage | Short term, +4°C. Long term, add glycerol to 40-50%, aliquot to avoid freeze/thaw cycles, and store at -20°C. Sensitive to light. |
| type | Primary |
| usage | The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. |
| target | BACE1 / BACE |
| predicted | aa72-121 |
| format | HRP Conjugated |
| clonality | Polyclonal |
| application | IHC - Paraffin, Western blot (applications tested for the base form of this product only) |