Anti-BACE1 / BACE Antibody (aa72-121) IHC-plus™ MX-B4664
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide located between aa72-121 of human BACE1 (P56817, NP_036236). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, |
|---|---|
| conjugations | Unconjugated.Also available conjugated with Biotin, FITC, HRP. |
| epitope | aa72-121 |
| failed | Distilled water |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (aa72-121) IHC-plus™ MX-B4664 |
| modifications | Unmodified |
| reactivity | Human, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Hamster, Horse, Pig, Rabbit |
| ncbi | P56817 |
| reconstitution | Chicken, Zebrafish (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Human BACE1 |
| storage | Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| usage | Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody. |
| target | BACE1 / BACE |
| predicted | aa72-121 |
| format | Unconjugated |
| clonality | Polyclonal |
| application | IHC - Paraffin, Western blot (applications tested for the base form of this product only) |