Anti-BACE1 / BACE Antibody (C-Terminus) IHC-plus™ MX-A8549
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic 18 amino acid peptide from C-terminus of human BACE1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Dog, Bat, Bovine, Hamster, Elephan |
|---|---|
| conjugations | Unconjugated |
| epitope | C-Terminus |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (C-Terminus) IHC-plus™ MX-A8549 |
| modifications | Unmodified |
| reactivity | Human, Monkey |
| ncbi | P56817 |
| reconstitution | Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Human BACE1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CPD (39%). |
| storage | Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles. |
| type | Primary |
| usage | Immunohistochemistry: MX-A8549 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, |
| target | BACE1 / BACE |
| predicted | C-Terminus |
| format | Unconjugated |
| clonality | Polyclonal |
| approved | IHC - Paraffin (2.5 - 5 µg/ml) |
| application | IHC - Paraffin |