Anti-BACE1 / BACE Antibody (C-Terminus) MX-C377
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide from human BACE1. |
|---|---|
| conjugations | Unconjugated |
| epitope | C-Terminus |
| furification | Ion exchange chromatography |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (C-Terminus) MX-C377 |
| modifications | Unmodified |
| reactivity | Human, Mouse |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | peptide corresponding to 17 amino acids at the carboxy terminus of human BACE |
| storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| type | Primary |
| target | BACE1 / BACE |
| predicted | C-Terminus |
| format | Unconjugated |
| clonality | Polyclonal |
| application | ICC, Western blot |