Anti-BACE1 / BACE Antibody MX-C12062
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against a 10 aa peptide near the NT of mouse BACE/Asp2 (1) conjugated to KLH. |
|---|---|
| conjugations | Unconjugated |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C12062 |
| modifications | Unmodified |
| reactivity | Mouse |
| ncbi | P56817 |
| reconstitution | Human, Rat (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | The mouse sequence has high degree of homology (100%) with human and 90% with rat BACE/Asp2. No significant sequence homology exists with BACE2/Aps1, a homolog of BACE, or other Asps. Antibody cross-reactivity in various species is not established. |
| storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| usage | Suitable for use in ELISA and Western Blot. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide per well. Western Blot: 1-10 ug/ml using ECL. |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | Western blot, ELISA |