Anti-BACE1 / BACE Antibody MX-C126948
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide corresponding to residues surrounding Asp490 of human BACE protein (KLH- coupled). |
|---|---|
| conjugations | Unconjugated |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C126948 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Rat |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Recognizes human BACE. |
| storage | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. |
| type | Primary |
| usage | Suitable for use in Western Blot and Immunoprecipitation. Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Immunoprecipitation: 1:50. |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Monoclonal |
| application | Western blot, Immunoprecipitation |