Anti-BACE1 / BACE Antibody MX-C155223
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against recombinant fragment corresponding to a region within amino acids 43 and 379 of BACE1 (SwissProt P56817). Percent identity by BLAST analysis: Human (100%); Bovine (99%); Mouse, Rat (98%); Xenopus (87%). |
|---|---|
| conjugations | Unconjugated |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C155223 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| reconstitution | Mouse, Rat, Bovine (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Human BACE1 |
| storage | Aliquot and freeze at -20° C. Avoid freeze-thaw cycles. |
| type | Primary |
| usage | Suggested starting dilutions are as follows: Western blot: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| approved | Western blot (1:500 - 1:3000) |
| application | Western blot |