Anti-BACE1 / BACE Antibody MX-C355637
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against synthetic peptide corresponding to aa485-501 (CLRQQHDDFADDISLLK) of human beta-secretase. Percent identity by BLAST analysis: Human, Gibbon, Monkey (100%); Mouse, Sheep, Dog, Bovine, Bat, Hamster, Horse, Pig (94%). |
|---|---|
| conjugations | Unconjugated |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C355637 |
| modifications | Unmodified |
| reactivity | Human, Gibbon, Monkey |
| ncbi | P56817 |
| reconstitution | Mouse, Bat, Bovine, Dog, Hamster, Horse, Pig, Sheep (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | The antibody detects transfected beta-secretase 1. It has been successfully used in ELISA, ICC/IF, Western blot and immunoprecipitation procedures. By Western blot, this antibody detects an ~70 kD protein representing beta-secretase 1 from HeLa cells tran |
| storage | Store at -20°C. Avoid freeze-thaw cycles. |
| type | Primary |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | ICC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA |