Anti-BACE1 / BACE Antibody MX-C3876
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against solubilized total recombinant protein. |
|---|---|
| conjugations | Unconjugated.Also available conjugated with AP, APC, Biotin, FITC, HRP, MaxLight 405, MaxLight 490, MaxLight 550, MaxLight 650, MaxLight 750, PE. |
| furification | Protein A/G purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C3876 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Recognizes human BACE1. Cross-reactivity with BACE2 is almost negligible. |
| storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| usage | Suitable for use in Western Blot. Western Blot: 0.25-1.0 ug/ml. Positive control: SH-SY5Y neuroblastoma cell lysate. |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | Western blot (applications tested for the base form of this product only) |