Anti-BACE1 / BACE Antibody MX-C498437
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against recombinant Human Beta-secretase 1 protein (46-155AA) |
|---|---|
| conjugations | Unconjugated.Also available conjugated with HRP, FITC, Biotin. |
| furification | Protein G purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody MX-C498437 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP |
| storage | Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles. |
| type | Primary |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | IHC, Immunofluorescence, ELISA (applications tested for the base form of this product only) |