Anti-BACE1 / BACE Antibody MX-C74520
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against nS0-derived rhBACE-1 ectodomain. |
|---|---|
| conjugations | Unconjugated |
| failed | 200 µl Sterile PBS |
| furification | Protein G purified |
| host | Mouse |
| antibody | Anti-BACE1 / BACE Antibody MX-C74520 |
| modifications | Unmodified |
| reactivity | Human, Mouse |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Recognizes human BACE-1 ectodomain. Species cross-reactivity: Mouse. |
| storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| type | Primary |
| usage | Suitable for use in ELISA, Immunoprecipitation/ Western Blot and Neutralization. The enzyme was then assayed with a peptide substrate. 50% of the proteolytic activity was inhibited by the antibody at 10 ug/ml (IC50) under conditions in which the enzyme wa |
| target | BACE1 / BACE |
| format | Unconjugated |
| clonality | IgG1 Monoclonal |
| application | Western blot, Immunoprecipitation, ELISA, Neutralization |