Anti-BACE1 / BACE Antibody (phospho-Ser498) IHC-plus™ MX-B5025
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| conjugations | Unconjugated |
|---|---|
| epitope | pSer498 |
| furification | Protein A purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (phospho-Ser498) IHC-plus™ MX-B5025 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| reconstitution | Mouse, Rat, Cow (at least 90% immunogen sequence identity) |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | This BACE Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE. |
| storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| type | Primary |
| target | BACE1 / BACE |
| predicted | pSer498 |
| format | Unconjugated |
| clonality | Polyclonal |
| application | IHC - Paraffin, Western blot |