Anti-BACE1 / BACE Antibody (Ser498, AP) MX-C275348
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| immunogen | BACE1 / BACE antibody was raised against kLH-conjugated synthetic phosphopeptide from amino acids around Ser498 of human BACE. |
|---|---|
| conjugations | Alkaline Phosphatase.Also available Unconjugated or conjugated with APC, Biotin, HRP, FITC, PE, MaxLight 405, MaxLight 490, MaxLight 550, MaxLight 650, MaxLight 750. |
| epitope | Ser498 |
| furification | Affinity purified |
| host | Rabbit |
| antibody | Anti-BACE1 / BACE Antibody (Ser498, AP) MX-C275348 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | P56817 |
| synonyms | NM_012104 NP_036236.1 |
| restrictions | For research use only. |
| specificity | Human BACE1 / BACE |
| storage | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months. |
| type | Primary |
| usage | The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. |
| target | BACE1 / BACE |
| predicted | Ser498 |
| format | AP Conjugated |
| clonality | IgG Polyclonal |
| application | IHC, Western blot, ELISA (applications tested for the base form of this product only) |