Anti-BACE2 Antibody (aa287-336, Biotin) MX-C449357
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide located between aa287-336 of human BACE2 (Q9Y5Z0, NP_620477). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Hor |
|---|---|
| conjugations | Biotin.Also available Unconjugated or conjugated with FITC, HRP. |
| epitope | aa287-336 |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (aa287-336, Biotin) MX-C449357 |
| modifications | Unmodified |
| reactivity | Human, Chimpanzee, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Chicken |
| ncbi | Q9Y5Z0 |
| reconstitution | Xenopus, Zebrafish (at least 90% immunogen sequence identity) |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Human BACE2 |
| storage | Short term, +4°C. Long term, add glycerol to 40-50%, aliquot to avoid freeze/thaw cycles, and store at -20°C. Sensitive to light. |
| type | Primary |
| usage | The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. |
| target | BACE2 |
| predicted | aa287-336 |
| format | Biotin Conjugated |
| clonality | Polyclonal |
| application | Western blot (applications tested for the base form of this product only) |