Anti-BACE2 Antibody (aa287-336) MX-C111126
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide located between aa287-336 of human BACE2 (Q9Y5Z0, NP_620477). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Hor |
|---|---|
| conjugations | Unconjugated.Also available conjugated with FITC, Biotin, HRP. |
| epitope | aa287-336 |
| failed | Distilled water |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (aa287-336) MX-C111126 |
| modifications | Unmodified |
| reactivity | Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Chicken |
| ncbi | Q9Y5Z0 |
| reconstitution | Xenopus, Zebrafish (at least 90% immunogen sequence identity) |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Human BACE2 |
| storage | Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| usage | Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody. |
| target | BACE2 |
| predicted | aa287-336 |
| format | Unconjugated |
| clonality | Polyclonal |
| application | Western blot (applications tested for the base form of this product only) |