Anti-BACE2 Antibody (aa325-340) MX-C2956
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide from human BACE2. Percent identity by BLAST analysis: Human, Monkey (100%); Dog (93%). |
|---|---|
| conjugations | Unconjugated |
| epitope | aa325-340 |
| furification | Protein G purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (aa325-340) MX-C2956 |
| modifications | Unmodified |
| reactivity | Human, Monkey |
| ncbi | Q9Y5Z0 |
| reconstitution | Dog (at least 90% immunogen sequence identity) |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | KLH conjugated synthetic peptide comprising amino acids 325 - 340 [RASLLYIQPMMGAGLC] of the human beta-site APP-cleaving enzyme 2 isoform C (BACE2) protein. |
| storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| target | BACE2 |
| predicted | aa325-340 |
| format | Unconjugated |
| clonality | Polyclonal |
| approved | ELISA (1:1000) |
| application | ELISA |