Anti-BACE2 Antibody (aa44-59) IHC-plus™ MX-B744
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide from human BACE2. |
|---|---|
| conjugations | Unconjugated |
| epitope | aa44-59 |
| furification | Purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (aa44-59) IHC-plus™ MX-B744 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Rat |
| ncbi | Q9Y5Z0 |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Amino acids 44 to 59 of human BACE2 |
| storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| type | Primary |
| usage | Immunohistochemistry: MX-B744 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, |
| target | BACE2 |
| predicted | aa44-59 |
| format | Unconjugated |
| clonality | Polyclonal |
| application | IHC - Paraffin, Western blot |