Anti-BACE2 Antibody (aa63-466) MX-C35084
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against nS0-derived rhBACE-2 (aa63-466). |
|---|---|
| conjugations | Unconjugated |
| epitope | aa63-466 |
| failed | 500 µl Reconstitute with sterile PBS |
| furification | Affinity purified |
| host | Sheep |
| antibody | Anti-BACE2 Antibody (aa63-466) MX-C35084 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | Q9Y5Z0 |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Selected for its ability to recognize human BACE-2 in direct ELISAs and Western Blots. In these formats, this antibody shows less than 1% cross-reactivity with rhBACE-1, rhCathepsin D and rhCathepsin E. |
| storage | For long term, store at -20°C. Avoid repeat freeze-thaw cycles. |
| type | Primary |
| usage | Western Blot: This antibody can be used at 0.1-0.2 ug/ml with the appropriate secondary reagents to detect human and mouse BACE-2. The detection limit for BACE-2 is approximately 5 ng/lane and 25 ng/lane under non-reducing and reducing conditions, respect |
| target | BACE2 |
| predicted | aa63-466 |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | Western blot, Immunoprecipitation, ELISA |