Anti-BACE2 Antibody (C-Terminus) MX-C188873
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide corresponding to aa near the C-terminus of human BACE2. |
|---|---|
| conjugations | Unconjugated |
| epitope | C-Terminus |
| furification | Affinity purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (C-Terminus) MX-C188873 |
| modifications | Unmodified |
| reactivity | Human |
| ncbi | Q9Y5Z0 |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Human BACE2. |
| storage | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at 12 months. |
| type | Primary |
| target | BACE2 |
| predicted | C-Terminus |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | IHC, Western blot, ELISA |