Anti-BACE2 Antibody MX-C355564
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide corresponding to aa503-518 (PEVVNDESSLVRHRWK) of human BACE2. Percent identity by BLAST analysis: Human, Monkey, Mouse, Bovine, Panda, Pig (100%); Marmoset (94%); Lizard, Xenopus (81%). |
|---|---|
| conjugations | Unconjugated |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody MX-C355564 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Bovine, Pig |
| ncbi | Q9Y5Z0 |
| reconstitution | Monkey (at least 90% immunogen sequence identity) |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | The antibody detects human beta-secretase 2 (BACE2). It has been successfully used in Western blot procedures. By Western blot this antibody detects an ~58 kD protein representing BACE2 in endogenous and overexpressing HEK-293 cells. It also detects two u |
| storage | Store at -20°C. Avoid freeze-thaw cycles. |
| type | Primary |
| target | BACE2 |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| approved | Western blot (1 µg/ml) |
| application | Western blot |