Anti-BACE2 Antibody (N-Terminus) MX-C121118
Details
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
| immunogen | BACE2 antibody was raised against synthetic peptide corresponding to amino acids near the N-terminus of Human BACE-2. |
|---|---|
| conjugations | Unconjugated |
| epitope | N-Terminus |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BACE2 Antibody (N-Terminus) MX-C121118 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Rat |
| ncbi | Q9Y5Z0 |
| synonyms | NM_012105 NP_036237.2 |
| restrictions | For research use only. |
| specificity | Recognizes human BACE-2. Species cross-reactivity: Mouse and rat. |
| storage | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C |
| type | Primary |
| usage | Suitable for use in Western Blot and Immunohistochemistry. Western Blot: 1 ug/ml. Immunohistochemistry: Paraffin. |
| target | BACE2 |
| predicted | N-Terminus |
| format | Unconjugated |
| clonality | IgG Polyclonal |
| application | IHC - Paraffin, Western blot |