Anti-BTK Antibody (Internal) MX-C413087
Details
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
| immunogen | BTK antibody was raised against kLH-conjugated synthetic peptide encompassing a sequence within the central region of human BTK. |
|---|---|
| conjugations | Unconjugated |
| epitope | Internal |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BTK Antibody (Internal) MX-C413087 |
| modifications | Unmodified |
| reactivity | Human, Monkey, Mouse, Rat, Bovine |
| ncbi | Q06187 |
| synonyms | NM_000061 NP_000052.1 |
| restrictions | For research use only. |
| specificity | Recognizes endogenous levels of BTK protein. |
| storage | Aliquot and store at -20°C for one year. Avoid freeze/thaw cycles. |
| type | Primary |
| target | BTK |
| predicted | Internal |
| format | Unconjugated |
| clonality | Polyclonal |
| application | IHC - Paraffin, Western blot |