Anti-BTK Antibody MX-C415527
Details
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
| immunogen | BTK antibody was raised against kLH-conjugated synthetic peptide from the C-terminal region of human BTK. |
|---|---|
| conjugations | Unconjugated |
| furification | Protein A purified |
| host | Rabbit |
| antibody | Anti-BTK Antibody MX-C415527 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Rat |
| ncbi | Q06187 |
| synonyms | NM_000061 NP_000052.1 |
| restrictions | For research use only. |
| specificity | BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) also known as X-linked agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD |
| storage | Store at -20°C. Avoid freeze-thaw cycles. |
| type | Primary |
| target | BTK |
| format | Unconjugated |
| clonality | Polyclonal |
| application | IHC, Western blot, ELISA |