Anti-BTK Antibody (N-Terminus) MX-C455
Details
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
| immunogen | BTK antibody was raised against synthetic peptide from human BTK. |
|---|---|
| conjugations | Unconjugated |
| epitope | N-Terminus |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BTK Antibody (N-Terminus) MX-C455 |
| modifications | Unmodified |
| reactivity | Human, Mouse |
| ncbi | Q06187 |
| synonyms | NM_000061 NP_000052.1 |
| restrictions | For research use only. |
| specificity | synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BTK |
| storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| type | Primary |
| target | BTK |
| predicted | N-Terminus |
| format | Unconjugated |
| clonality | Polyclonal |
| application | ICC, Western blot |