Anti-BTK Antibody (phospho-Tyr223) MX-C416342
Details
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members.
| immunogen | BTK antibody was raised against synthetic peptide from human BTK around the phosphorylation site of Tyrosine 223. |
|---|---|
| conjugations | Unconjugated |
| epitope | pTyr223 |
| furification | Immunoaffinity purified |
| host | Rabbit |
| antibody | Anti-BTK Antibody (phospho-Tyr223) MX-C416342 |
| modifications | Unmodified |
| reactivity | Human, Mouse, Rat |
| ncbi | Q06187 |
| synonyms | NM_000061 NP_000052.1 |
| restrictions | For research use only. |
| specificity | Phospho-BTK(Tyr223) Antibody detects endogenous levels of BTK only when phosphorylated at Tyrosine 223. |
| storage | Store at -20°C for up to one year. |
| type | Primary |
| target | BTK |
| predicted | pTyr223 |
| format | Unconjugated |
| clonality | Polyclonal |
| approved | Western blot (1:500 - 1:2000) |
| application | Western blot |