MP20003 BCL-10 Primary Antibody MP20003 [M4F8]
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Details
Application
| Application | FCM, WB, IHC, ELISA, ICC |
|---|---|
| ELISA | 1/10000 |
| ICC (Immunocytochemistry) | 1/100- 1/500 |
| FCM (Flow Cytometry) | 1/200 - 1/400 |
| IHC | 1/200 - 1/400 |
| WB (Cell Lysate) | 1/200 - 1/1000 |
TARGET
| UniProtKB | O95999 (BCL10_HUMAN) |
|---|---|
| Protein | B-cell lymphoma/leukemia 10 |
| Gene | BCL10 |
| Organism | Homo sapiens (Human) |
| Molecular function | CARD domain binding Source: UniProtKB enzyme binding Source: UniProtKB identical protein binding Source: IntAct kinase binding Source: UniProtKB NF-kappaB binding Source: UniProtKB protease binding Source: BHF-UCL protein C-terminus binding Source: UniProtKB protein kinase B binding Source: UniProtKB protein kinase binding Source: UniProtKB protein self-association Source: UniProtKB transcription coactivator activity Source: UniProtKB transcription factor binding Source: UniProtKB ubiquitin protein ligase binding Source: UniProtKB |
| Biological process | adaptive immune response Source: UniProtKB B cell apoptotic process Source: Ensembl cell death Source: UniProtKB cellular defense response Source: Ensembl cellular response to mechanical stimulus Source: UniProtKB Fc-epsilon receptor signaling pathway Source: Reactome I-kappaB kinase/NF-kappaB signaling Source: GO_Central immunoglobulin mediated immune response Source: Ensembl innate immune response Source: UniProtKB interleukin-6 biosynthetic process Source: UniProtKB lipopolysaccharide-mediated signaling pathway Source: UniProtKB lymphotoxin A biosynthetic process Source: UniProtKB negative regulation of mature B cell apoptotic process Source: UniProtKB neural tube closure Source: UniProtKB positive regulation of apoptotic process Source: UniProtKB positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ARUK-UCL positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB positive regulation of interleukin-8 biosynthetic process Source: UniProtKB positive regulation of kinase activity Source: GOC positive regulation of mast cell cytokine production Source: UniProtKB positive regulation of NF-kappaB transcription factor activity Source: UniProtKB positive regulation of phosphorylation Source: UniProtKB positive regulation of protein ubiquitination Source: UniProtKB positive regulation of T cell activation Source: Ensembl positive regulation of transcription, DNA-templated Source: UniProtKB protein complex oligomerization Source: UniProtKB protein heterooligomerization Source: Ensembl protein homooligomerization Source: UniProtKB protein ubiquitination Source: Reactome regulation of T cell receptor signaling pathway Source: Ensembl response to food Source: UniProtKB response to fungus Source: Ensembl response to molecule of bacterial origin Source: UniProtKB stimulatory C-type lectin receptor signaling pathway Source: Reactome T cell apoptotic process Source: Ensembl T cell receptor signaling pathway Source: UniProtKB toll-like receptor signaling pathway Source: UniProtKB |
| Protein names | Recommended name: B-cell lymphoma/leukemia 10 Alternative name(s): B-cell CLL/lymphoma 10;Bcl-10;CARD-containing molecule enhancing NF-kappa-B;CARD-like apoptotic protein;hCLAP;CED-3/ICH-1 prodomain homologous E10-like regulator;CIPER;Cellular homolog of vCARMEN;cCARMEN;Cellular-E10;c-E10;Mammalian CARD-containing adapter molecule E10;mE10 |
| Subcellular location | perinuclear region Membrane raft Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts. |
| Pathology & Biotech | Involvement in disease A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. Immunodeficiency 37 (IMD37) The disease is caused by mutations affecting the gene represented in this entry. Disease descriptionA form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive. Lymphoma, mucosa-associated lymphoid type (MALTOMA) The disease is caused by mutations affecting the gene represented in this entry. Disease descriptionA subtype of non-Hodgkin lymphoma, originating in mucosa-associated lymphoid tissue. MALT lymphomas occur most commonly in the gastro-intestinal tract but have been described in a variety of extranodal sites including the ocular adnexa, salivary gland, thyroid, lung, thymus, and breast. Histologically, they are characterized by an infiltrate of small to medium-sized lymphocytes with abundant cytoplasm and irregularly shaped nuclei. Scattered transformed blasts (large cells) also are present. Non-malignant reactive follicles are observed frequently. A pivotal feature is the presence of lymphoepithelial lesions, with invasion and partial destruction of mucosal glands and crypts by aggregates of tumor cells. |
| Interaction | Subunit structure Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex (PubMed:27113748). Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity). Interacts with CARD11 and MALT1; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation. |
Sequence
| Length | 233 |
|---|---|
| Mass (Da) | 26,252 |
| Sequence |
10 20 30 40 50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS
160 170 180 190 200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA
210 220 230
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
|
| conjugations | N/A |
|---|---|
| host | mouse |
| antibody | Mouse Monoclonal antibody |
| modifications | N/A |
| reactivity | human, mouse, rat |
| presentation | 0.01% Sodium azide |
| purification | Protein A purified |
| storage | [-20°C] |
| target | BCL-10 |
| format | Liquid |
| clonality | [M4F8] |
| application | FCM, WB, IHC, ELISA, ICC |