MCT33989 AMTB [926023-82-7]

AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat. For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg.

参考文献：
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溶解度： Soluble in DMSO
保存条件： -20℃
配置溶液浓度参考：
1mg 5mg 10mg
1 mM 2.32 ml 11.601 ml 23.202 ml
5 mM 0.464 ml 2.32 ml 4.64 ml
10 mM 0.232 ml 1.16 ml 2.32 ml
50 mM 0.046 ml 0.232 ml 0.464 ml
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